摘要
线性染色体的末端是由重复序列TTAGGG组成,称为端粒,由于DNA的不完全复制正常体细胞随着细胞分裂的进行而逐渐丢失端粒序列。肿瘤细胞通过表达端粒酶———一种RNA依赖性DNA聚合酶而补偿端粒序列的丢失,从而保持端粒的长度。近90%的人类肿瘤可检测到端粒酶活性,而正常体细胞缺乏这种酶的活性。本文综述了端粒,端粒酶的功能及其与肿瘤的相关性,论及了端粒酶作为肿瘤诊断的标志及肿瘤治疗的新靶点。
The ends of linear chromosomes are composed of a repeated sequence,TTAGGG,which are known as telomeres. Normal somatic cells progressivelly lose telomeric repeats with each successive cell division due to DNA incomplete replication.Cancer cells compensate for telomeric loss by expressing the enzyme telomerase,an RNA-dependent DNA polymerase that maintains telomere length.Telomerase activity has been detected in almost 90%of all human cancers,but is generally absent in normal somatic cells.This review summarized structure and function of telomere and telomerase and their relation to cancer,as well as the potential value of telomerase as a diagnostic marker and a new therapeutic target for cancer.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1998年第2期121-126,共6页
The Chinese Journal of Clinical Pharmacology
关键词
端粒
端粒酶
肿瘤治疗
telomeres
telomerase
cancer therapy