丙种球蛋白治疗小儿反复呼吸道感染26例

IVIG Massive Drip Intravenous Therapy of Recurrent Respiratory Tract Infection in Infants—Analysis of 26 Cases

目的：探讨静脉滴注大剂量丙种球蛋白（ＩＶＩＧ）治疗小儿反复呼吸道感染的治疗效果。方法：对２６例患儿以５００ｍｇ／ｋｇ静脉滴注ＩＶＩＧ，每月１次，连续３月。对照组２０例，按常规治疗，不用免疫制剂及血浆。用单向免疫琼脂扩散法和间接免疫荧光法，分别检测治疗前后患儿血清ＩｇＧ、ＩｇＡ、ＩｇＭ、ＣＤ３、ＣＤ４和ＣＤ８，并临床追踪观察１年。结果：ＩＶＩＧ组总有效率为８８．４％，对照组为５０．５％，差异有显著性。治疗后ＩｇＧ、ＣＤ３、ＣＤ４和ＣＤ４／ＣＤ８明显升高（Ｐ＜０．０１），ＣＤ８降低，而对照组治疗前后各免疫指标无明显差异。结论：静脉滴注大剂量ＩＶＩＧ能提高ＲＲＴＩ患儿体液和细胞免疫水平，减少发病次数。

Objective:To study the efficacy of recurrent respiratory tract infection in infantsMethods:IVIG was given intravenously to 26 infantile patients with recurrent respiratory infection in a dose of 500 mg/kg once a month for 3 months.In the control group of 20 cases normal treatment was performed without the administration of immunosuppressant and plasma.Before and after the treatment respective measurement of IgG,IgA,IgM,CD3,CD4,and CD8 was carried out with single direction immunological diffusion method and indirect immufluorescent method.All the patients wee fllowed up for one year.Results:The efective rate is 88.4% for the IVIG group and 50.0% for the control group,a difference of remarkable significance.There is an evident increase in the level of IgG,CD3,CD4,and CD4/CD8(P<0.01) and a decrease in CD8 in the IVIG proup wherease no significant differences are found in all the immune indexes in the control group.Conclusion:Massive intravenous drip of IVIG can raise the level of infantile humoral and cellular immunity and reduce the morbidity.Therefore,it is an effective therapy of infantile recurrent respiratory tract infection.