P53蛋白表达水平与大肠腺癌病理及预后的探讨

Study of the Relation Between P53 Expression and Pathological Factors in Colorectal Carcinoma and It,s Prognostic Significance

应用免疫组织化学方法对４０例大肠腺癌Ｐ５３蛋白表达进行检查，探讨Ｐ５３蛋白表达水平与大肠腺癌各病理因素及预后的关系。发现５０％（２０／４０）大肠腺癌组织中存在Ｐ５３蛋白表达，其表达程度与大肠腺癌各项病理因素无关；Ｐ５３蛋白表达阳性患者５年生存率为２５％（５／２０），明显低于Ｐ５３蛋白表达阴性组的６０％（１２／２０），Ｐ＜０．０５。结果提示：Ｐ５３免疫组化检测可以作为判断大肠腺癌预后的指标。

? The expression of P53 protein in 40 cases of large bowel adenocarcinoma was studied immunohistochemically by use of a monoclonal antibody DO7 in this study. And immunoreactivity was found in 50% of them. The pattern of P53 expression was mainly detected in the nuclei of the tumor cells. No significant correlation between the expression of P53 and tumor size, pattern of growth, differention or lymph node metastasis was found. However patients with P53 positive tumors had a greater relative risk of death compared with those with P53 negative tumors. The 5 year survival rate was 25% of 20 patients with P53 positive tumors and 65% of the patients with P53 negative tumor. There was a significant different in the rate between the two groups of patients(P<0.05).The result suggest that the immunoreactivity of P53 may be act as a prognostic indicator in adenocarcinoma of large bowel.