实验性大脑中动脉供血区梗塞的心电图动态观察

Electrocardiogram Observation in Experimental Model of Cerebral Infarction in the Territory of Middle Cerebral Artery

目的：证实脑梗塞能否引起心电图（ＥＣＧ）异常。方法：７０只Ｗｉｓｔａｒ鼠（雄３３，雌３７）分成对照组（２０）和模型组（５０），模型组制成不开颅的大脑中动脉（ＭＣＡ）供血区梗塞动物模型。动物麻醉后，用监护仪记录对照组和模型组手术前后的ＥＣＧ。结果：对照组手术前后ＥＣＧ正常。模型组ＭＣＡ阻塞前，所有动物ＥＣＧ正常，ＭＣＡ阻塞后２３只Ｗｉｓｔａｒ鼠出现ＥＣＧ异常，表现为ＳＴ段上抬（２３／５０），房扑（４／５０），频发室性早博（６／５０）。６５．２％的ＥＣＧ异常发生在ＭＣＡ阻塞后３ｈ内，最短为３５ｍｉｎ。结论：Ｗｉｓｔａｒ鼠ＭＣＡ阻塞后能引起ＥＣＧ异常。

? Objective: To Confirm whether Electrocardiogram(ECG) abnormality can be induced by cerebral infarction. Methods: 70 Wistar rats were divided into the model group (50) and the control group (20). The cerebral infarction in the territory of middle cerebral artery (MCA) was made without craniotomy in the model group. After anesthesia ECG was recorded with monitor in the both group. Result: ECG was normal in the control group and the model group before MCA occluded, but ECG abnormality was found in 23 Wistar rats after MCA occluded. It presented elevated ST (23/50), atrial flutter (4/50) and highfrequency ventricular premature (6/50). 62.5% ECG abnormality occurred after 3 hours of MCA occluded and the shortest one was 35 minutes. Conclusion: ECG abnormality can be induced by MCA occluded in Wistar rats.