125例活动性肝炎肝硬变和重型肝炎患者医院感染的分析

Clinic Analysis of Active Cirrhosis and Fulminant Hepatitis Complicate Nosocomial Infection (A Report of 125 Cases)

对我院１９９２～１９９５年６５例活动性肝炎肝硬变和６０例重型肝炎患者进行回顾性医院感染调查，发现发生医院感染４２例，医院感染发生率为３３．６％（４２／１２５），其中活动性肝炎肝硬变和重型肝炎医院感染发生率分别为１８．５％（１２／６５）和５０．０％（３０／６０），后者显著高于前者（Ｐ＜０．０５）；感染部位以腹腔、肠道和呼吸道多见；共培养出细菌１１种１８株，多为条件致病菌，且以肠道细菌多见，并普遍存在耐药；并发医院感染患者黄疸加深，肝硬变病人死亡率增加。认为：预防医院感染对活动性肝硬变和重型肝炎的治疗和预后判断有重要意义。

? Authors retrospectly investigated nosocomial infection (NI) in the 65 cases of active cirrhosis and 60 cases of fulminant hepatitis who had inpatiented in the year 1992￣1995 in our hospital, found that there had been 42 cases of NI, the NI ratio of active cirrhosis and fulminant hepatitis were 18.5% (12/65) and 50% (30/60) respectively, the later was significant higher than the fomer (P<0.05);the body places of NI were common in abdominal cavity, intestine and respiratory tract; there were 11 species bacteria, most of them were conditional pathogenic bacteria, intestine bacteria played primary role, and they were resistant to many antibiotics; patients, with NI jundice was higher and mortality of active cirrhosis with NI was higher than that of without NI (both P<0.05). So authors thought that:preventing NI has important significance in treatment and prognosis of active cirrhosis and fulminant hepatitis.