骨形成蛋白-5、A型受体及Smad1,4,5在Tca8113舌癌细胞的表达及意义

Expression of BMP-5, BMPR-ⅠA and Smad1,4,5 in Tongue Carcinoma Tca8113 Cell

目的 认识和分析骨形成蛋白 (BMP)及其信号传导因子与口腔鳞癌发生、发展的可能关系。 方法 用免疫组织化学方法检测 BMP- 5、 A型 BMP受体及 Smad1,4 ,5在 Tca8113舌癌细胞中的表达并分析其意义。结果 BMP- 5、 A型 BMP受体及 Sm ad1,4 ,5在 Tca8113细胞中有表达。其中在细胞质中发现有 BMP- 5的阳性信号 ,在细胞膜中有 A型 BMP受体的阳性信号 ,在细胞质、细胞核中有 Sm ad1,4 ,5的强阳性表达。

Objective\ To study the relationships between bone morphogenetic proteins(BMP), BMP receptors type ⅠA, Smad1,4,5 and squamous cell carcinoma of oral epithelia.\ Methods\ Expressions of BMP\|5, BMPR\|ⅠA and Smad1,4,5 in Tca8113 cell were analyzed by immunohistochemistry.\ \{Results\}\ All of Tca8113 cell showed positive staining for BMP\|5, BMPR\|ⅠA and Smad1,4,5.\ The positively staining cell of BMP\|5 consistently exhibited in cytoplasm.\ Positive signals of BMPR\|ⅠA were found in cytomembrane consistently.\ Positive signals of Smad1,4,5 in nucleoplasm were obtained consistently.\ Conclusion\ BMP\|5, BMPR\|ⅠA and Smad1,4,5 might be involved in occurrence and development of squamous cell carcinoma of oral epithelium.\;