花生凝集素受体在急性上颌窦炎粘膜的表达及意义

Expression and Significance of the Peanut Agglutinin Receptor in Mucosas of Acute Maxillary Sinusitis

目的 利用已建立的实验动物模型 ,探讨花生凝集素 (PNA)受体在急性上颌窦炎粘膜中的表达及意义。 方法 将急性炎症标本及正常鼻窦粘膜标本行凝集素亲和组织化学 ABC法染色。 结果 对照组鼻窦粘膜染色基本阴性 ,炎症粘膜呈弱阳性。 N- PNA(预先经神经氨酸酶处理后再进行 PNA染色 )染色均显著加深。 结论上颌窦急性炎症期 ,花生凝集素受体的表达发生改变 ,这种改变可能一方面是致病菌侵袭的结果 。

Objective\ To study the expression and significance of the receptor of peanut agglutinin(PNA) in mucosas of acute maxillary sinusitis.\ Methods\ Inflamed mucosas and normal sinus \{mucosas\} were studied with lectin\|binding histochemistry ABC method.\ Results\ Nearly negative expression of PNA was observed in the normal mucosas, but the staining reactivity of inflamed mucosas was weak positive.\ The degree of staining reactivity with N\|PNA(PNA with neuramidinase pretreatment) was deeper than DNA.\ \{Conclusion\}\ The expression of the receptor of PNA in mucosas of acute maxillary sinusitis was increased, and the changes are a result both of pathogenic microganisms invasion and defensive mechanisms against microorganisms during the stages of the inflammatory process.\;