尖锐湿疣中乳头瘤病毒感染与P53和ki-67表达的关系

Relations between HPV Infection and the Expression of P53 and ki-67 in Condylama Acuminatum

目的 探讨尖锐湿疣中乳头瘤病毒 (HPV)感染与 P5 3和 ki- 6 7的关系。 方法 采用免疫组织化学方法对 82例尖锐湿疣的 HPV感染、P5 3和 ki- 6 7的表达进行观察。 结果 HPV阳性者 2 4例 (2 9.3% ) ,P5 3阳性表达 2 0例 (2 4 .4 % ) ,ki- 6 7阳性表达 2 1例 (2 5 .6 % )。2 4例 HPV阳性者中 ,P5 3阳性表达 10例 (41.7% ) ,ki- 6 7阳性表达 11例 (45 .8% ) ,经关联分析 ,皮损中 HPV感染与 P5 3(χ2 =4 .2 4 7,P<0 .0 5 )和 ki- 6 7(χ2 =5 .6 8,P<0 .0 5 )阳性表达均有显著关联 ;而 P5 3与 ki- 6 7两者均阳性者仅有 6例 (χ2 =0 .98,P>0 .0 5 ) ,无明显关联。 结论 在尖锐湿疣中 HPV感染伴随 P5 3和 ki- 6

Objective\ To investigate relations between human papilloma virus(HPV) infection and the expression of P53 and ki\|67 in condyloma acuminatum(CA).\ Methods\ The expression of HPV, P53 and ki\|67 was observed by immunohistochemical staining in 82 condyloma acuminatum.\ Results\ HPV infection and expression of P53 and ki\|67 were found in 24 cases(29 3%), 20 cases(24 4%) and 21 cases(25 6%), respectively.\ There were 10 positive expression of P53(41 7%) and 11 positive expression of ki\|67(45 8%) in 24 HPV infection, and it has shown that HPV infection is closely related to P53 positive expression(χ\+2=4 247,P<0 05) and ki\|67 positive expression(χ\+2=5 68,P<0 05) in condyloma acuminatum.\ There was 6 cases ki\|67 positive expression in 20 cases P53 positive expression and no relations between P53 and ki\|67 expression were found(P>0.05).\ Conclusion\ HPV infection is accompanied by increase of P53 and ki\|67 expression in CA.\;