哮喘患儿血清嗜酸性粒细胞阳离子蛋白改变及其意义

Changes of Serum Eosinophil Cationic Protein and its Significance in Asthmatic Children

目的 评价变应性哮喘患儿血清嗜酸性粒细胞阳离子蛋白 (S- ECP)水平改变及其意义。 方法 测定 2 5例哮喘发作期患儿糖皮质激素吸入治疗 12周前后 ,及 2 0例未予糖皮质激素吸入治疗的哮喘缓解期患儿 S-ECP水平 ,并对发作期患儿 S- ECP水平变化与血嗜酸性粒细胞计数 (B- EOS)、肺功能一秒用力呼气量 (FEV1 )、一秒用力呼气量比用力肺活量 (FEV1 / FVC)及症状评分的关系作相关性分析。 结果 哮喘发作组治疗后 S- ECP水平较治疗前显著降低 ,与对照组 (健康儿童 10名 )比较差异无显著性 ;哮喘缓解组 S- ECP水平明显高于发作组治疗后 ,但明显低于发作组治疗前。哮喘发作组治疗前 S- ECP水平变化与 B- EOS无相关性 ,与 FEV1 、FEV1 / FVC呈负相关 ,与症状评分呈正相关。 结论 监测 S- ECP水平可作为评价哮喘气道炎症程度。

Objective\ To investigate serum eosinophil cationic protein(S\|ECP) levels in allergic asthma and its clinical significance.\ Methods\ S\|ECP from 25 asthma attacks before and after treatment with inhaled corticosteroids(continued for 12 weeks ), and 20 patients no taking inhaled corticosteroids in stable conditions were tested.\ Correlation of S\|ECP with blood eosinophil count(B\|EOS), lung function FEV\-1, FEV\-1/FVC and symptom score was studied in pre\|treatment group of attacks, respectively.\ \{Results\}\ S\|ECP levels in post\|treatment group were significantly decreased, as compared with pre\|treatment group, while there was no significant difference between S\|ECP levels in post\|treatment group and those in control.\ S\|ECP levels in stable conditions were significantly higher than those in post\|treatment group, but significantly lower than in pre\|treatment group.\ S\|ECP correlated well with FEV\-1, FEV\-1/FVC and symptom score, but poorly with B\|EOS.\ Conclusion\ Monitoring of S\|ECP levels may effectively act as a marker to evaluate airway inflammation and patient's condition, and as a guide for anti\|\{inflammation\} therapy in asthma.\;