大鼠-兔异种异位心脏移植模型的建立

A Model of Rat to Rabbit Heterotopic Cardiac Xenotransplantation

目的 研究非协调性异种心脏移植 ,建立大鼠 -兔异位心脏移植模型。 方法 以 SD大鼠为供体 ,新西兰白兔为受体 ,应用袖套技术 ,将供心主动脉与受体颈总动脉、供心肺动脉与受体颈外静脉吻合。 结果 完成实验 4 8例 ,手术成功率 10 0 %。供心缺血时间 12± 5 min,吻合时间 2～ 4 min。 结论 应用袖套技术建立大鼠 -兔异位心脏移植模型 ,克服了腹腔心脏移植的局限性 。

Objective\ To study the discordant cardiac xenotransplantation, the model of rat to rabbit heterotopic cardiac xenotransplantation was established.\ Methods\ Sprague\|Dawley rats served served as donors and New Zealand white rabbits as the recipients.\ The aorta and the main pulmonary artery of the donor were anastomosed with the right common carotid artery and the external jugular vein of the recipient respectively with the cuff technique.\ Results\ 48 times of formal transplantation were done with the successful rate being 100%.\ The ischemic time of the donor heart were 12±5 minutes and the anastomosis time were only 2~4 minutes.\ Conclusion\ In this model, the localization in the model of celiac cardiac xenotransplantation is overcome and the transplanting technique is simplified.\;