急性脑血管病患者血清胃泌素的临床研究

Changes of serum gastrin in patients with acute cerebrovascular disease

目的 了解脑血管病患者血清胃泌素含量的动态变化及与临床的关系。方法 应用放射免疫法测量 40例脑出血和6 0例脑梗死患者于发病后第 3、7、14、2 1天血清胃泌素的含量 ,并与 40例对照组比较。结果 急性脑血管病患者发病后血清胃泌素水平升高 ,随着病程延长逐步降低 ,峰值时间为第 7天 ,第 2 1天降至对照组范围。在各时间点疾病组间无明显差异。脑出血未破入脑室或无消化道出血者 ,血清胃泌素水平在第 2 1天降至正常 ;而破入脑室或伴消化道出血者 ,在第 2 1天时血清胃泌素仍高于正常对照组。血清胃泌素水平与出血量有关。结论 脑血管病患者于发病后血清胃泌素水平变化与临床有密切关系 ,这为应用抗酸剂治疗提供了理论依据。

Objective To observe the dynamic change ofserum gastrin and the relationship with clinical symptoms in patients with acute cerebrovascular disease. Methods Serum gastrins were measured by radioimmunoassay in 40 patients with cerebral hemorrhage and 60 with cerebral infarctionat days 3,7,14 and 21 after stroke respectively and were compared with that of40 control subjects. Results The level of serum gastrin elevated after stroke. The peak time of serum gastrin happened at day 7 and the level of serum gastrin turn down to that of normal subjects at day 21. There was no significant difference in 4 different times. For these patients whose blood did not enter intocerebral ventricles or the patients without the bleeding of the digestive tract,the level of serum gastrin reduced to the normal subject level at day 21 afterstroke. While the patients with cerebral hemorrhage whose blood entered into cerebral ventricles or whose digestive tract symptoms appeared had higher gastrin than the control group. Moreover the level of serum gastrin was related to hemorrhage volume. Conclusion The dynamic change of serum gastrin in patients with cerebrovascular disease is related to clinical symptoms. These provide theoretic basis for the clinical application of anti-acid drugs.