^(131)I治疗Graves甲亢近期疗效评价

Short-term effects of radioiodine treatment on Graves' hyperthyroidism

目的 评价放射性碘 (13 1I)治疗毒性弥漫性甲状腺肿 (Graves病 )的近期临床疗效。方法 对接受13 1I治疗的 2 78例Graves甲亢患者随访 1年。所有病人于治疗后 3、6、12个月复诊。治疗结果包括治愈 (包括治疗后甲状腺功能恢复正常与发生甲低 )和未愈 (甲亢 )。结果 治疗后 3个月 ,有 179例 (6 4 3%)患者甲状腺功能恢复正常 ,35例 (12 6 %)发生甲低 ,6 4例(2 3 1%)仍处于甲亢 ,治愈率为 76 9%。治疗后半年与一年的治愈率相似 (84 6 %vs 88 8%) ,均显著性高于 3个月 ,分别有193例 (6 9 5 %)和 196例 (70 5 %)甲状腺功能恢复正常 ,42例 (15 1%)和 5 1例 (18 3%)发生甲低。结论 13 1I能迅速治愈甲亢 ,疗效显著 ,简便安全 ,是成人Graves甲亢的首选治疗方法。

Objective To evaluate the short-term efficacy of radioiodine ( 131 I)therapy in Graves' hyperthyroidism. Methods A total of 278 patients with Graves' disease were treated with a single dose of 131 I. All patients were followed up for one year and reexamined at 3,6 and 12 months after 131 I treatment.Results Of the 278 patients, 76.9%(214/278)were cured after 3 months withradioiodine.While after 6 and 12 months,the cure rates were similar(84.6% vs 88.8%),and both were higher than that after 3 months. Conclusion A single dose of 131 I is highly effective for curing Graves' hyperthyroidism,so it is used as first line therapy for adult Graves's hyperthyroidism.