大蒜素抗鼠巨细胞病毒性肝炎的实验研究

Experimental Study on the Treatment of Mouse Cytomegalovirus Hepatitis by Garlic

选择大蒜素进行小鼠体内抗巨细胞病毒 (MCMV)性肝炎的初步研究。将 6～ 8周龄雌性 BAL B/C小鼠于腹腔接种病毒第 2 d即开始每日腹腔注射大蒜素注射液 ,持续 2周。取小鼠肝组织作 β- gal染色以检测 MCMV及 HE染色以观其病理改变情况并将其血清送化验室测 s AL T。结果发现 :给予大蒜素治疗组的小鼠的肝脏病理改变程度较模型组轻 ,其 s AL T值亦较低 ,其肝组织切片内的 β- gal染色阳性率亦较低 ,说明大蒜素在小鼠体内具有抗

week female BALB/C mice were subjected to the intraperitoneal inoculation of murine cytomegalovirus (MCMV). On the second day, the mice received intraperitoneal injection of injection garlic for 2 weeks. β gal staining was made on the murine hepatic tissue for detecting MCMV and HE staining was done for observing pathological examination. Serum ALT was measured. The results demonstrated that the pathologic lesions of the mice treated with garlic were milder, sALT was lower and the cells positive for β gal staining in liver tissue sections were fewer than in the model group. The results suggested that the garlic had the effect against the MCMV hepatitis in mice in vivo .