血清抗Sa抗体检测及临床意义

Detection and clinical significances of anti-Sa antibody in serum

目的 检测类风湿性关节炎 (RA)患者血清抗Sa抗体 ,并探讨Sa抗体对RA的诊断意义。方法 Western blot方法。结果 抗Sa抗体诊断RA的敏感度为 42 .7% ,特异度为 1 0 0 % ,阳性确诊率为 1 0 0 % ,阴性确诊率为71 1 %。结论 血清抗Sa抗体对RA诊断的特异度和阳性确诊率均高于类风湿因子 (RF) ,因此具有临床实用价值。

Objective To detect anti Sa antibody in rheumatoid arthritis (RA) serum and prove the significances of seral anti Sa antibody in diagnostic RA. Methods Western blot method. Results The sensitivity, specificity, PPV and NPV were 42.7%,100%,100% and 71 1% respectively. Conclusion Diagnostic specificity and PPV of seral anti Sa antibody to RA patients were better than rheumatoid factor (RF) and practical suggested its in clinical value.