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MSC_s向神经细胞横向分化的研究与质疑 被引量：2

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摘要 骨髓问质干细胞(mesenchymal stem cells,MSCs)可横向分化为神经细胞,这种跨系分化在体外可单独诱导分化为神经元,而在体内可能与神经干细胞(neural stem cells,NSCs)或胚胎干细胞(embryonic stem cells,ESCs)产生融合,由融合细胞分化为神经细胞,这一过程被误解为横向分化,故而横向分化仍需深入研究。
作者 张化彪
机构地区 华中科技大学同济医学院附属同济医院神经内科
出处 《国外医学（神经病学．神经外科学分册）》 2002年第6期525-528,共4页 Foreign Medical Sciences（Section On Neurology & Neurosurgery）
关键词 骨髓间质干细胞 神经细胞 横向分化 研究 神经系统疾病 治疗
分类号 R741.02 [医药卫生—神经病学与精神病学]
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参考文献20

  • 1Reyes M, Lund T, Lenvik T, et al. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood, 2001, 98(9): 2615-2625.
  • 2Barry F, Boynton R, Murphy M, et al. The SH-3 and SH-4 antibodies recognize distinct epitopes on CD73 from human mesenchymal stem cells. Biochem Biophys Res Commun, 2002, 290(5): 1609.
  • 3Minguell JJ, Conget P, Erices A. Biology and clinical utilization of mesenchymal progenitor cells. Braz J Med Biol Res, 2000, 33(8): 881-887.
  • 4Awad HA, Butler DL, Harris MT, et al. In vitro characterization of mesenchymal stem cell-seeded collagen scaffolds for tendon repair: effects of initial seeding density on contraction kinetics. J Biomed Mater Res, 2000, 51(2): 233-240.
  • 5Justesen J, Stenderup K, Kessem MS. Mesenchymal stem cells. Potential use in cell and gene therapy of bone loss caused by aging and osteoporosis. Ugeskr Laeger, 2001, 163(40): 5491-5495.
  • 6Colter DC, Class R, DiGirolamo CM, et al. Rapid expansion of recycling stem cells in cultures of plastic adherent cells from human hone marrow. Proc Natl Acad Sci USA, 2000, 97(7): 3213-3218.
  • 7Lennon DP, Edmison JM, Caplan AI. Cultivation of rat marrow-derived mesenchymal stem cells in reduced oxygen tension: effects on in vitro and in vivo osteochondrogenesis. J Cell Physiol, 2001, 187(3): 345-355.
  • 8Kopen GC, Darwin JP, Donald GP. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci USA, 1999, 96(19): 10711-10716.
  • 9Brazelton TR, Rossi FMV, Keshet GI, et al. From Marrow to Brain: Expression of Neuronal Phenotypes in Adult Mice. Science, 2000, 290(5497): 1175-1179.
  • 10Mezey E, Karen JC, Gyongyi H, et al. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science, 2000, 290 (5497): 1179-1182.

同被引文献19

  • 1张田勤.干细胞研究一波三折[N].文汇报(科技文摘),2001-8—15(11).
  • 2奚永志 吴祖泽.成年组织干细胞到底怎么了?[N].健康报,2003—01-6(2).
  • 3John M. Assistive technology-psyched about stem cells [ N ]. Business Week Online. 2001-08-09.
  • 4Chapman AR, Franel MS, Garfinkel MS. Stem cell research and apptication: monitoring the frontiers of biomedical research[M]. Produced by the American for the advancement of acience and institute for civil aociety,1999.1-7, 11-15.
  • 5IFreed CR, Breeze RE, Rosenberg NL, et al. Embryonic dopaminecell implants as a treatraent for the second plase of Parklnsan's disease:replacing failed nerve te.rminals[J ]. Adv Neurol, 1993, 60:721-728.
  • 6Spencer DD, Robbins R J, Naftolin F, et al. Unilateral transplantatbn of hturum fetal mesenceplalic tissue into the caudate nucleus of patients with Parkinsan's disease[J]. N Engl J Med, 1992, 327:1541-1548.
  • 7Cho T, Bae J. H, Choi, H. B, et al. Human neural stem cells: electrophysiological properties of voltage-gated ion channels[J]. Membrane And Cellular Biophysics And Biochemistry,2002;13(11):1447
  • 8Dl Clarke . Neural stem Cells[M]. Bone Marrow Transplantation,2003:13-17
  • 9刘泉开.神经干细胞研究进展[J].现代诊断与治疗,2000,11(5):257-259. 被引量：2
  • 10刘平,卢亦成,朱诚.中枢神经干细胞[J].中华神经外科杂志,2000,16(3):196-198. 被引量：7

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国外医学（神经病学．神经外科学分册）
2002年 第6期

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