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谷氨酸转运蛋白与神经系统疾病 被引量：5

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摘要 脑组织具有明显收集谷氨酸的能力,而转运蛋白是使谷氨酸从细胞外液有效地被转走的唯一功能单位,也是长期维持谷氨酸在细胞外低浓度和无毒性的重要因素。谷氨酸转运蛋白在调节神经传导方面似乎也有着较复杂的功能,它们调节突触间的时程,突触外间隙与邻近突触之间受体激活和失活的程度及方式,同时也为γ-氨基丁酸,谷胱甘肽和蛋白质的合成及能量的产生提供谷氨酸。像谷氨酸一样,谷氨酸转运蛋白与谷氨酸有关的突触的正常功能的维持和某些神经系统疾病(如脑缺血,肌萎缩性侧索硬化,阿尔茨海默病,创伤性脑损伤及癫痫等)相关。
作者 黄月明
机构地区 中南大学湘雅医院神经外科
出处 《国外医学（神经病学．神经外科学分册）》 2002年第6期547-550,共4页 Foreign Medical Sciences（Section On Neurology & Neurosurgery）
关键词 谷氨酸转运蛋白 神经系统疾病 脑缺血 肌萎缩性侧索硬化
分类号 R741.02 [医药卫生—神经病学与精神病学]
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参考文献15

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同被引文献46

  • 1窦国睿,刘涛,李金莲.囊泡膜谷氨酸转运体在神经系统的研究进展[J].神经解剖学杂志,2005,21(1):87-90. 被引量：6
  • 2李爱林,只达石,黄慧玲.谷氨酸的兴奋性毒性与脑创伤[J].国外医学（神经病学．神经外科学分册）,2005,32(3):231-234. 被引量：9
  • 3Springer JE, AzbiI1 RD, Mark RJ, et al. 4-Hydroxynonenal, A Lipid Peroxidationproduct, Rapidly Accumu fates Following Traumatic Spinal Cord Injury and In hibits Glutamate Uptake[J].J Neurochem (S0022 - 3042),1997,68:2469--2476.
  • 4Saito Y, Kato A, Hagihara Y, et al. Gene Therapy for Ischemic Brain Diseases[J]. Curr Gene Ther(S1566-- 5232), 2003,3(1) :49--58.
  • 5Tsuboniwa N, Morishita R, Hirano T, et al. Safety evaluation of Hemagglutinating Virus of Japan-artificial Viral Envelope Liposomes in Nonhuman Primates[J]. Hum GeneTher(S1043- 0342) ,2001,12(5):469- 487.
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  • 9JEN J C, WAN J, PALOS T P, et al. Mutation in the Glutamate Transporter EAAT1 Causes Episodic Ataxia, Hemiplegia, and Seizures [J].Neurology, 2005, 65(4): 529-534.
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引证文献5

二级引证文献4

国外医学（神经病学．神经外科学分册）
2002年 第6期

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