GnRH-a在体外受精—胚胎移植中的应用

Application of gonadotropin releasing hormone agonists (GnRH-a)in vitro fertilization and embryo transplantation

目的:探讨促性腺激素释放激素激动剂 (Gn RH- a)在体外受精—胚胎移植 (IVF- ET)中的作用。 方法 :2 0 0 1年 5月～ 2 0 0 2年 7月共行 IVF- ET3 9例 ,对已获成功的 2 0例患者进行回顾性研究。用达菲林或阿拉瑞林进行降调节 ,其中长方案从治疗周期前一周期的黄体中期开始应用 ,月经第 3天用促性腺激素 (Gn) ;短方案自治疗周期月经第 2天开始应用 ,第 3天开始用促性腺激素 (Gn)。结果:长方案组用达菲林全量 10例 ,半量 6例 ,用阿拉瑞林1例 ;短方案组达菲林 1例 ,阿拉瑞林 2例。结论 :实施 IVF- ET,Gn RH- a在控制性超排卵 (COH)中具有至关重要的意义 ,可有效防止过早 L H峰、减少取消周期 。

Objective: To summarize the application of gonadotropin releasing hormone agonists (GnRH a) for in vitro fertilization (IVF). This article is a review of the successful 20 cases for IVF ET and will be benefit for the future work. Methods: We used Diphereline or A1arelin for down regulation. GnRH a was started in the luteal phase before this cycle and Gn was given from the third day of cycle in long regime, and GnRH a was started in the second day of cycle and Gn was given from the third day of cycle in short regime. Results: We did 39 cases of IVF cycle, there were 20 cases of clinical pregnancy in which 10 cases used full quantity of Dipheraline and 6 cases used a half quantity, 1 case used Alarelin. Conclusion: It is very important on controlled ovarian hyperstimulation (COH) by using GnRH a in IVF. It prevents early LH surges reduces cancel cycle and improves pregnancy rate.