^(153)Sm—EDTMP治疗乳腺癌骨转移疼痛的临床疗效观察

The Clinical Observation of Palliative Treatme nt of Metastatic Bone Pain with ^(153)Sm-EDTMP in Breast Cancer Patients

目的 :评价153 Sm—乙二胺四甲基膦酸 (153 Sm—EDTMP)对乳腺癌转移性骨痛的镇痛效果。方法 :采用两次给药法静脉注射153 Sm—EDTMP对 76例乳腺癌骨转移疼痛患者进行治疗。结果 :治疗后骨痛完全缓解者 2 5例 ,中度缓解者 4 0例 ,总有效率为 85 5 2 % (6 5 / 76 )。除Ⅲ度以内的血液学毒性反应外 ,未见其它严重的毒副作用。结论 :153 Sm—EDTMP能有效地缓解乳腺癌骨转移疼痛 ,且副作用小 ,是一种安全、有效的治疗方法。

Objective:To evaluate the effect of 153 Sm-EDTMP in palliative treatment for the pain of osseous metastases in breast cancer.Methods:Seventy-six patients with painful bone metastases of breast cancer were enrolled in the study and treated by intravenous administration of 153 Sm-EDTMP in two doses.Results:The overall response rate was 85. 52%(65 of 76 cases).The patients who experienced prompt pain relief with complete response(25 cases of 76)and partial response(40 cases)were 32. 89% and 52. 63%,respectively.Except in hematological toxicity grade 3,no severe adverse effects were observed.Conclusions: 153 Sm-EDTMP was safe and effective for fast relieving pain caused by bone metastases from breast cancer.