1Li J,Yen C,Liaw D,et al.PTEN a putative protein tyrosine phosphatase gene mutated in human brain,breast,and prostate cancer.Science,1997,275(5308):1943-1947
2Steck PA,Pershouse MA,Jasser SA,et al.Identification of a candidate tumour suppressor gene,MMAC1,at chromosome 10q23.3 that is mutated in multiple advanced cancers.Nat Genet,1997,15(4):356-362
3Li DM,Sun H.TEP1,encoded by a candidate tumor suppressor locus,is a novel protein tyrosine phosphatase regulated by transforming growth actor beta.Cancer Res,1997,57(11):2124-2129
4Furnari FB,Lin H,Huang HS,et al.Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain.Proc Natl Acad Sci USA,1997,94(23):12479-12484
5Li J,Simpson L,Takahashi M,et al.The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene.Cancer Res,1998,58(24):5667-5672
6Yuan XJ,Whang YE.PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway.Oncogene,2002,21(2):319-327
7Davies MA,Koul D,Dhesi H.Regulation of Akt/PKB activity,cellular growth,and apoptosis in prostate carcinoma cells by MMAC/PTEN.Cancer Res,1999,59(11):2551-2556
8Tamura M,Gu J,Matsumoto K,et al.Inhibition of cell migration,spreading,and focal adhesions by tumorsuppressor PTEN.Science,1998,280(5369):1614-1617
9Gu J,Tamura M,Yamada KM.Tumor suppressor PTEN inhibits integrin and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways.J Cell Biol,1998,143(5):1375-1383
10Giri D,Ittmann M.Inactivation of the PTEN tumor suppressor gene is associated with increased angiogenesis in clinically localized prostate carcinoma.Hum Pathol,1999,30(4):419-424
