胎盘组织中Beclin-1、P62表达与晚发型子痫前期患者围生儿结局的相关性

The correlation between the expression of Beclin-1 and P62 in placental tissue and perinatal outcomes in patients with late--onset preeclampsia

目的探讨胎盘组织中Beclin-1、P62表达与晚发型子痫前期患者围生儿结局的相关性。方法采用回顾性研究的方法,收集2021年1月至2023年12月于中国科学技术大学附属第一医院完成分娩的186例晚发型子痫前期患者的资料,根据围生儿不良结局发生情况分为结局不良组(n=45)与结局良好组(n=141)。比较两组胎盘组织中Beclin-1、P62相对表达量及其他一般资料,通过Logistic回归模型及限制性立方样条法分析胎盘组织中Beclin-1、P62相对表达量与晚发型子痫前期患者围生儿结局的相关性。结果结局不良组胎盘组织中Beclin-1相对表达量高于结局良好组,P62相对表达量低于结局良好组(P<0.05)。结局不良组疾病严重程度重度占比高于结局良好组(P<0.05)。Logistic回归分析显示,晚发型子痫前期患者围生儿结局与胎盘组织中Beclin-1、P62表达情况及疾病严重程度有关(P<0.05)。限制性立方样条法分析结果显示,晚发型子痫前期患者围生儿不良结局发生风险与胎盘组织中Beclin-1、P62表达水平呈线性剂量反应关系(P<0.05)。结论晚发型子痫前期患者围生儿结局可能与胎盘组织中Beclin-1、P62表达有关。

Objective To explore the correlation between the expression of Beclin-1 and P62 in placental tissue and the perinatal outcomes of late--onset preeclampsia patients.Methods A retrospective study was conducted to collect data from 186 patients with late-onset preeclampsia who completed delivery in hospitals from January 2021 to December 2023.According to the occurrence of adverse outcomes in the perinatal period,they were divided into a poor outcome group(n=45)and a good outcome group(n=141).The relative expression of Beclin-1 and P62 in placental tissues and other general data were compared between the two groups.The correlation between the relative expression of Beclin-1 and P62 in the disc tissue and the perinatal outcome of patients with late-onset preeclampsia was analyzed utilizing Logistic regression model and restricted cubic spline method.Results The relative expression level of Beclin-1 in placental tissue of the poor outcome group was higher than that of the good outcome group,and the relative expression level of P62 was lower than that of the good outcome group(P<0.05).The proportion of severe disease severity in the poor outcome group was higher than that in good outcome group(P<0.05).Logistic regression analysis showed that the perinatal outcomes of late--onset preeclampsia patients were related to the expression of Beclin-1 and P62 in placental tissue and the severity of the disease(P<0.05).The results of the restricted cubic spline method analysis showed that the risk of adverse perinatal outcomes in late-onset preeclampsia patients was linearly dose-response related to the expression levels of Beclin-1 and P62 in placental tissue(P<0.05).Conclusions The perinatal outcomes of late-onset preeclampsia patients may be related to the expression of Beclin-1 and P62 in placental tissue.