益气活血醒脑开窍法治疗大鼠中风痴呆

Nourishing Qi activating blood and resuscitation in the treatment of apoplectic demential rats

目的 探讨益气活血、醒脑开窍法治疗中风痴呆的可行性 .方法 采用改良的Pulsinelli 4 血管阻断法建立痴呆大鼠模型 ,随机分组 ,分别给予吡拉西坦及醒脑丸内服 ,同时设立正常及模型对照 ,观察大鼠用药后机体状态、活动情况及学习游水迷宫的能力 ,并进行海马CA1区形态学检测 .结果 醒脑丸组大鼠机体状态明显改善 ,游水迷宫时间较模型组及西药组短 (2 6 2± 4 2vs 6 3 2± 4 2 ,P <0 0 1;2 6 2± 4 2vs 5 8 5±3 0 ,P <0 0 1) ,海马CA1区神经元坏死脱失减轻及反应性星形胶质细胞增生程度均较西药组显著 .结论 具有益气活血、醒脑开窍功效的方药醒脑丸能够提高大鼠学习、记忆能力 。

AIM To assess the possibility of nourishing Qi, activating blood and resuscitation in treating apoplectic dementia. METHODS An improved method of 4 vascular occlusion was adopted to make the dementia rat model and they were divided randomly into groups. The piracetam and Xing Nao pillow(XN pillow) were taken respectively. At the same time, the normal and model groups were set up. The rats` organism states, activities and the ability of swimming in water maze after training were examed. And the morphology of hippocampi CA1 area was also carried out. RESULTS Compared XN pillow group with the model group and piracetam group, the XN pillow group rats organism states were apparently improved than the other two, and the time they cast in swimming water maze were apparently short(26 2±4 2 vs 63 2±4 2, P <0 01; 26 2±4 2 vs 58 5±3 0, P <0 01). And reducing the necrosis of neurons and the reactive proliferation of astrocyte in hippocampi CA1 area of the rats were more significant in XN pillow group than in piracetam group. CONCLUSION XN pillow, the Chinese medicine with the function of nourishing Qi, activating blood and resuscitation could increase the abilities of learning and memory of rats, and could improve the tolerance of hippocampi CA1 area to ischemia damage.