克山病人血浆心钠素和头发微量无素硒相关性分析

Experimental Analysis of the Correlativity between Atrial Natriuretic Polypeptide and Hair Selenium in Patients with Keshan Disease

对29例潜在型、慢型克山病患者的血浆心钠素水平及发硒含量分别用放射免疫直接测定法和2,3——二氨基萘荧光法进行测定。结果表明,克山病患者血浆心钠素含量显著高于对照组(P<0.001),而发硒含量与对照组无显著性差异(P>0.05),发硒含量与血浆心钠素值无明显相关性(P>0.05)。提示心肌损害及功能发生改变后心钠素分泌、释放增加。补硒对患者血浆心钠素含量无明显影响。

We determined respectively the contents of both atrial natriuretic polypeptide (ANP) in the plasma and selenium in the hair of 29 patients with latent or chronic Keshan disease by the method of radioimmunoassay and 2,3-diaminonaphthalene fluorescence assay. The results of investigation demonstrated that ANP content in the plasma of patients with Keshan disease was obviously higher than that of normals in control (P< 0.001). The difference of selenium content between the experimental and control groups was not significant (P>0.05). It seems that there was not significant correlation between selenium content in the hair and the ANP content in the plasma in both the experimental and the control groups (P>0.05). From this fact, we consider that release and secretion of ANP increase after myocardium damage and myocardial function change, that selenium supplement has not any effect on the ANP content in the latent or chronic patients with myocardial dysfunction.