生长分化因子9基因的研究进展

Advance on Growth Differentiation Factor 9 Gene

转化生长因子β( TGF-β)超家族成员对卵巢卵泡的发育起着重要的作用 ,在这个超家族中发现 1个新成员生长分化因子 ( GDF-9) ,它对早期卵泡和卵母细胞的生长是必需的。本文主要阐述了生长分化因子 9基因结构和功能、基因克隆以及在小鼠、人类和绵羊卵巢中的作用机理 ,并讨论了该基因对繁殖性能的影响。

Transforming growth factor β(TGF-β)superfamily is important to normal follicular development. A novel member of the TGF-β superfamily termed growth differentiation factor 9(GDF-9) was shown to be essential for early follicular and oocyte growth. This review introduced structure,function,molecular cloning of GDF-9 gene and its physiological mechanism in ovaries of mouse, human and sheep. The relationship between GDF-9 gene and fertility was also discussed.