口服[^(35)S]阿苯达唑亚砜感染细粒棘球蚴的小鼠体内的吸收、分布与排泄

Absorption, Distribution and Excretion of 〔^(35)S〕 Albendazole Sulfoxide Given Orally to Mice Infected with Secondary Cysts of Echinococcus ranulosus

感染小鼠口服[^(35)S]阿苯达唑亚砜150mg/kg(含0.74MBq)后lh,血中的^(35)S浓度达高峰值,2～4h后降低至峰值的1/2,24h后大部分已消除。小鼠口服药物后0.5h,即可在各脏器中测得^(35)S的含量,在0.5～2h达高峰值,至8h迅速下降,24～48h大部分消除。囊壁的高峰值为血峰值的53％,正常鼠口服[^(35)S]阿苯达唑150mg/kg(含0.67MBq)后72h,尿、粪的累计排泄率分别为89.2％和6.4％。

Mice, infected with secondary cysts of Echinococcus granulosus for 10 months, were treated orally with 〔35S〕 albendazole sulfoxide 150mg/kg (containing 0.74 MBq). One hour after medication, peak radioactivity appeared in blood, and then declined to one half of the peak value 2-4 hours later. 24 hours after medication, most of the radioactivity eliminated in the blood. The 35S activity was also detected rapid-ly in various visceral organs and reached to peak value within 0.5-2 hours after treatment. Afterwards, the radioactivity declined rapidly and almost eliminated 24-48 hours later. In cyst wall, the peak 35S activity was 53% of that in corresponding blood. When non-infected mice were treated orally with 〔35S〕 albendazole sulfoxide 150mg/kg (containing 35S 0.67 MBq) for 72 hours, the accumulated rats of 35S activity excreted from urine and feces were 89.2% and 6.4%, respectively.