口服不同剂量的碘化油微囊防治地方性甲状腺肿的疗效及有效期观察

Observation of the Effect and Effective Duration of Oral Microcapsules of Iodized Oil at Different Doses for Endemic Goiter Control

本文报告1990～1991年在缺碘性疾病流行区新疆托克逊县观察了一次性口服不同剂量(400、300和200mg)碘化油微囊的防治疗效及尿碘排泄。结果表明,在服药后半年和1年甲状腺肿患病率在不同剂量组均有不同程度的下降,治愈率均有不同程度的提高,但与对照组比较无论患病率还是治愈率均无显著差异(P>0.05)。不同剂量组之间服药后1月内尿碘排泄有随剂量增大相应增高的趋势(P<0.01),但至第三个月时无论是不同剂量组之间还是与对照组之间均未见显著差异(P>0.05)。从而提示,口服碘化油微囊能否作为防治缺碘性疾病的长效补碘方法,很值得商榷。

From 1990 to 1991, an observation was carried out in IDD prevalent areas of Toksun County, Xinjiang to evaluate the effect of microcapsules of iodized oil by different single doses (400mg, 300mg and 200mg, respectively) on endemic goiter control and to investigate urinary iodine excretion of people in the areas. Results showed that goiter morbidity fell in different degrees, 6 months and 12 months after oral administration of iodized oil at different doses, and that cure rates for goiter improved to some extent, however, no statistical significance was found in the differences of morbidity or cure rate as compared with those of the control group (P > 0.05). and urinary iodine excretion increased correspondingly with the increment of the dosage (P<0.01) at all the 3 doses within 1 month after administration, but after 3 months, no significant differences existed either among the study groups or in their comparison with the control (P>0.05). It is suggested, therefore, that the value of oral microcapsules of iodized oil as a means of long-term iodine supplementation in endemic goiter control remains questionable.