克山病病区粮喂饲大鼠对维生素E需要量的初步探讨

Preliminary Study of Vitamin E Requirement of Rats Fed with Diet from Keshan Disease Affected Areas

克山病病区粮或在其中补充硒及不同剂量的维生素E喂饲大鼠12周,以其心肌脂质过氧化物为指标,初步证明病区粮喂饲大鼠对维生素E的最低需要量为200mg/kgDL-α-生育酚。同时还证明,在硒充足时对维生素E的需要量明显降低。在大鼠心肌,维生素E抗自由基作用强于硒。

Keshan disease (KD) is an endemic cardiomyopathy occurring in China. Combined selenium and vitamin E deficiency might be involved in the development of KD. It was shown in this paper that vitamin E requirement of rats fed a low selenium diet contained grains cultivated in KD affected region was 200mg / kg DL-α-tocopherol, and which was decreased in the presence of selenium. The action that vitamin E counteracted free radicals in myocardium of rats appeared greater than that of selenium.