托氟沙星治疗急性细菌性感染

Tosufloxacin in treating acute bacterial infection

目的 :评价托氟沙星治疗各种急性细菌性感染的临床疗效及安全性。方法 :70例急性感染性病人 ,按双盲双模拟、区组分层均衡随机法分成 2组 ,托氟沙星组 35例 [男性 11例 ,女性 2 4例 ,年龄(34±s 16 )a],用托氟沙星 15 0mg ,potid。司帕沙星组 35例 [男性 12例 ,女性 2 3例 ,年龄 (32± 13)a],用司帕沙星 30 0mg ,po ,qd。均 7～ 14d为一个疗程。结果 :托氟沙星组痊愈率为 72 % ,有效率为86 % ,细菌清除率为 90 % ,不良反应发生率为5 % ,司帕沙星组痊愈率为 4 9% ,有效率为 77% ,细菌清除率为 77% ,不良反应发生率为 7% ,2组比较 ,差异均无显著意义 (P >0 .0 5 )。结论 :托氟沙星治疗急性细菌性感染有效且安全 。

AIM: To evaluate the efficiency and safety of tosufloxacin in treating acate bacterial infection. METHODS: Seventy patients with acute infective disease were divided into two groups by randomization and double blind method. The tosufloxacin groups of thirty five patients (M 11, F 24; age (34± s 16) a) were treated with tosufloxacin 150 mg, tid. The control group of thirty five patients (M 12, F 23; age (32±13) a) were given sparfloxacin 300 mg, qd. Two groups all were given orally for 7 14 d. RESULTS: The cured rate and the effective rates were 71 % and 86 % in tosufloxacin group, and 49 % and 77 % in control group ( P >0.05). The clearance rate of bacterium and the adverse reaction rate were 90 % and 5 % in tosufloxacin group, and 77 % and 7 % in control group, respectively ( P > 0.05 ). CONCLUSION: Tosufloxacin and sparfloxacin have the similar efficiency and safety in the treatment of acute bacterial infection.