神经节苷脂治疗急性脑梗死

Ganglioside G(M_1) in treating acute cerebral infarction

目的 :观察神经节苷脂治疗急性脑梗死的疗效。方法 :急性脑梗死 6 0例 ,分为神经节苷脂组及对照组。神经节苷脂组 30例 ,给予 6 0～ 10 0mg加入氯化钠注射液 2 5 0mL ,iv ,gtt× 2wk ;对照组30例 ,给予胞磷胆碱 0 .5～ 0 .75 g或吡拉西坦 4 g ,治疗 2wk ,于治疗前、治疗后 1wk和 2wk对 2组病人进行神经功能缺损程度 (NDS)及日常生活活动量 (ADL)评分 ,并进行比较。结果 :神经节苷脂组与对照组疗效比较经Ridit分析 ,差异有显著意义 (P<0 .0 5 ) ,治疗后wk 1,2NDS和ADL评分与治疗前相比 ,差值分别为 (- 12 .0±s 0 .5 )分 ,(- 3.3±0 .3)分 ;(- 17.4± 0 .7)分 ,(- 4.5 4± 0 .2 5 )分 ;(31.8± 2 .4 )分 ,(2 .1± 0 .6 )分 ;(5 2± 10 )分 ,(6± 6 )分 (P <0 .0 1)。结论 :神经节苷脂治疗急性脑梗死有显著的疗效 ,能促进神经功能的早期恢复 。

AIM: To observe the efficacy of ganglioside G(M 1) in treating cerebral infarction. METHODS: Sixty patients with acute cerebral infarction were divided into GM 1 ganglioside group and control group. GM 1 ganglioside group of thirty patients received ganglioside GM 1 60-100 mg, iv, gtt, qd×2 wk. Control group of thirty patients received citicoline 0.5-0.75 g or piracetam 4 g, iv, gtt, qd×2 wk. The effect of two groups was analysed with Ridit. The NDS and ADL were compared before and after 1 and 2 wk treatment. RESULTS: There was a significant difference in effect between the two groups ( P <0.01) by Ridit analysis. After 1 and 2 wk treatment, the margins of NDS were -12.0±0.5, -3.3±0.3; -17.4± 0.7 , -4.54±0.25( P <0.01), respectively between two groups; the margins of ADL were 31.8± 2.4 , 2.1±0.6; 52±10, 6±6 ( P <0.01). CONCLUSION: ganglioside G(M 1) has a better effect in the treatment of acute cerebral infarction. It can recover the nerve function early and improve the quality of life of patients.