纳络酮治疗弥漫性轴索损伤

Effects of naloxone in treatment of diffuse axonal injury

目的 :观察纳络酮治疗弥漫性轴索损伤的疗效。方法 :15例为纳络酮组 ,其中男性 10例 ,女性 5例 ,年龄 (41.0±s 2 .0 )a ,格拉斯哥昏迷分级(GCS)为 (4.2± 1.5 )分。 18例为对照组 ,其中男性12例 ,女性 6例 ,年龄 (39± 4 )a ,GCS为 (4.1± 1.9)分。对照组给予 2 0 %甘露醇注射液 ,iv ,纳络酮组除给予 2 0 %甘露醇注射液静脉注射外 ,给予纳络酮注射液 4mg·d- 1,iv ,治疗时间为 2 0d。采用颅脑损伤转归分级 (GOS)的标准评价治疗结果。结果 :采用纳络酮治疗的病人 ,良好率为 6 0 % (9/ 15 ) ,对照组良好率为 17% (3/ 18)。 2组比较P <0 .0 5。未见不良反应。结论 :采用纳络酮治疗弥漫性轴索损伤的病人 。

AIM: To assess effects of naloxone in the treatment of diffuse axonal injury (DAI). METHODS: Fifteen patients(M 10, F 5;age(41.0± s 2.0) a; GCS 4.2±1.5) of DAI were treated with naxolone. The other eighteen patients (M 12,F 6;age(39±4)a;GCS 4.1±1.9) of DAI were treated on routine. The routine group was mainly given intravenous 20 % mannitol. The naloxone group was given naloxone 4 mg·d -1 , intravenously besides routine. Glasgow outcome scale (GOS) was adopted to evaluate the efficacy. The treatment duration was 20 d. RESULTS: Patients who received in naloxone had a higher recovery rate 60 %(9/15) and in routine had a lower recovery rate 17 %( 3/18 ). There was a very significantly difference in two groups ( P <0.05). CONCLUSION: This data has confirmed that early application of naloxone can significantly improve the quality of life of patients without adverse reactions.