摘要
为探讨抗纤灵冲剂对大鼠肾脏急性缺血再灌注(I-R)后血流动力学的干预作用,观察各组SD雄性大鼠在I-R血BUN、Scr,ET、TXB2和6-Keto-PGF1α,血NO、NOS及组织NO的变化情况。结果:抗纤灵冲剂明显降低I-R大鼠的血BUN、Scr(P<0.05),可调节TXA2和PGI2的合成比例,稳定血NO、NOS及组织NO。结论:抗纤灵冲剂对改善I-R后血流动力学的紊乱,保护肾功能有效。
To approach the effect of KangXianLing decoction and its main-herb on the intervention of hemodynamics in rats after ischemic-reperfusion. The male SD rats were divided into 5 group ( normal, sham-operated, experimental model, ZhiDaHuang?Dan-Shen, Monopril and KangXianLing group. The changes of plasma blood urea nitrogen (BUN),serum creatinine(Scr) , endothelin-1 (ET),thromboxance B2 (TXB2), 6-Keto-Prostaglandin-Fi?6-Keto-PGFi,,), nitric oxide synthase (NOS) , plasma and renal-tissue nitric oxide (NO) were detedted in each group after ischemic-reperfusion. The results showed that KangXianLing decoction and its main-herb significantly made BUN,Scr reduced (P<0. 05), adjusted synthesing ratio of thromboxance A2(TXA2)and prostacy-clin(PGI2),stabilized the content of plasma NO,NOS and renal-tissue NO. Conclusion-Kang XianLing decoction can remit the disorder of hemodynamics by I-R. So it can prevent renal function injury from renal ischemia.
出处
《上海实验动物科学》
2002年第4期218-222,共5页
Shanghai Laboratory Animal Science
基金
教育部高等学校骨干教师资助计划资助(编号:2000-35)
