新生儿缺氧缺血性脑病PAF和脑血流动力学的变化

Changes in blood platelet-activating factor levels and cerebral hemodynamics in neonatal hypoxic ischemic encephalopathy

目的 探讨血小板活化因子 (PAF)在新生儿缺氧缺血性脑病 (HIE)发病机制中的作用。 方法 采用放射免疫法测定 5 0例新生儿HIE外周血中PAF的含量 ,并与 15例正常新生儿进行对照 ;同时采用经颅彩色多普勒仪 (TCD)同期检测患儿脑血流动力学的变化。 结果 HIE患儿急性期PAF水平较正常新生儿显著升高 (P <0 0 1) ,且患儿脑血流动力学紊乱。 结论 PAF参与了新生儿HIE的发病过程 ,其含量与病情严重程度呈正相关。PAF直接或间接影响脑血管的调节机制 ,脑血流动力学能快速。

Objective To explore the role of blood platelet activating factor (PAF) in pathogenesis of neonatal hypoxic ischemic encephalopathy (HIE). Methods Blood PAF was measured in 50 neonates with HIE by means of radio immunoassay and compared with that in 15 normal term neonates. Transcranial Doppler sonography (TCD) was used to evaluate the index of cerebral hemodynamics in children with HIE. Results Blood PAF levels were much higher in acute stage of HIE and cerebral hemodynamics were disturbed significantly. Conclusions PAF might play an important role in pathogenesis of neonatal HIE. PAF could directly or indirectly affect the mechanism of regulation in cerebral vessels; the index of hemodynamics in brain could promptly and sensitively reflect the changes in blood flow of cerebral arteries.