甲氨喋呤血药浓度监测在髓外白血病防治中的应用

Study of the blood concentration of M TX in the treatment of children leukemia out of spinal

目的探讨大剂量甲氨喋呤在小儿髓外白血病防治中的药代动力学改变及血药浓度监测的临床意义。方法52例急性淋巴细胞性白血病患儿,为预防髓外白血病应用大剂量甲氨喋呤3.0g/m2,治疗3个疗程,每疗程进行3次血药浓度监测。结果用药后24小时血药浓度出现峰值,48小时回复到用药时水平。结论根据测定的甲氨喋呤血药浓度水平结合临床,可适当缩短给药间期或增加药物剂量。

Objective To investigate the pharmacokinetic s and pharmacodynamics of high dose o f MTX in the treatment of children leukemia out of spinal.Methods Fifty-two children received 3.0g /m 2 MTX for three times in each course of t reat-ment and the blood concentration of M TX was monitored.Results The peaks of blood concentration of M TX appeared at 24th after administration and returned t o the beginning level at 48th.Conclusion The study indicates that proper shortening of in-tervals between administration or i ncreasing the dosage may provide more effective treatment for children l eukemia.