乳腺癌组织中GST-π和PCNA的表达及临床意义

Expression and significance of GST -πand PCNA in breast cancer

目的探讨乳腺癌组织中GST-π的表达及可能的作用机制。方法采用免疫组化S-P法,并结合增殖细胞核抗原(PCNA)表达及临床分期,研究乳腺癌组织中GST-π及PCNA的表达。结果①乳腺癌中GST-π表达为63.6%(28/44),临床III期表达显著高于临床I、II期。②PCNA在乳腺癌组织中高表达为72.7%,在淋巴结转移组和非转移组之间,差异有显著性意义(P<0.01);③GST-π与PCNA表达呈正相关。结论PCNA的阳性率与淋巴结转移有关,联合GST-π检测,对乳腺癌化疗药物的选择及预后的判断有参考价值。

Objective To investigate the expression of GST-πand the PCNA and their possible roles in breast can-cer.Methods Using the S -P immunohistochemistry,and combining the tumor clinic stage,to study on the expression of GST -πand the PCNA in breast cancer.Results The expression of GST -πin breast cancer was 63.6%,compared with I and II clinic stages,the expression of GST -πin III clinic stage breast cancer was higher.The expression of PCNA was 72.7%,there was apparent difference between the lymphous -node -transfer group and n on -lymphous -node -transfer group.The expression of GST -πand PCNA in breast cancer has positiv e correlation.Conclusion The expression of PCNA was related to the lym-phous -node -transfer;Combining the level of GST -πcan contribute to select the chemoth erapic drugs and prognosis evaluati on of breast cancer.