鼻咽未分化癌22例放疗结果分析

Undifferentiated nanopharyngeal c arcinoma in 22patients

目的分析鼻咽未分化癌放疗结果。方法1984～1996年放射治疗鼻咽未分化癌22例,用Kaplan-Meier法进行生存统计,Log-rank检验。结果全组3、5、10年生存率分别为49.2%、44.6%、30.5%;Ⅲ期16例,IVa期6例,3、5、10年生存率分别为42.6%、39.5%、29.1%和56.8%、46.9%、33.3%,生存曲线无差异;鼻咽原发灶肉眼消退中位剂量DT53Gy;9例共计23条颅神经受浸润,疗终颅神经症状好转率(消失+减轻)为91.3%(21/23);7例出现鼻咽颈淋巴结复发,中位复发期29月;8例出现血行转移,中位转移期11月。结论鼻咽未分化癌对放疗敏感,血行转移是早期致死的主要原因,需采取综合治疗以降低血行转移。

Objective To analyze the radiotherapy effect o f undifferentiated nanopharyngeal carcinoma (UNPC).Methods 22patients with UNPC were treated by radiotherapy from 1984to 1996in whi ch.16patients in stageⅢ,6patients in stage IVa.Results The 3～,5～,10～year survival rates we re 49.2%?44.6%?30.5%,respectively .16patients in stageⅢand 6patients in stage IVa,3～,5～,10～year survival rates were 42.6%?39.5%?29.1%and 56.8%?46.9%?33.3%,respectively(P>0.05).The median of dose was D T 53Gy for tumor regression in nasopharyngeal cavity.23cranial nerves in9patients were damaged,complete recovery and partial recovery rates of 23cranial nerves were 91.3%(21/23)after radiotherapy.The median of recurrence was 29month s for 7patients with nasopharynx cervical lymph node recurrence .The med ian of metastasis were 11months for 8patients with metastasis.Conclusions UNPC is sensitive to radiotherapy.Metastasis is main factor in early death patients.Combined modality o f UNPC is suggested.