抑癌基因p16在非小细胞肺癌中的表达及其意义

Expression of p16 in Human Non-Small Cell Lung Cancer and It's Significance

目的 探讨非小细胞肺癌 (NSCLC)中抑癌基因p16的表达及其意义。方法 用免疫组化ABC法检测鼠抗人p16单克隆抗体在 5 9例原发性NSCLC中的表达。结果 p16在非小细胞肺癌中的阳性表达率为 47.5 % (2 8 5 9)。p16的阳性表达在NSCLC中不同的大体类型、肿块直径大小、病理组织学分类等方面均无显著性差异 (P >0 .0 5 )。但p16在NSCLC的淋巴结转移组的阳性表达率为2 5 .0 % ,显著低于淋巴结无转移组的阳性表达率 67.7% (P <0 .0 5 )。结论 p16的缺失表达对非小细胞肺癌的淋巴结转移起重要作用 。

Objective To study the expression of p16 in human non-small cell lung cancer and it's significance to pathogenesis,clinical type and lymphnode metastasis of this cancer.Methods 59 cases of NSCLC were detected by using ABC immunohistochemical technique.Results The positive rate of p16 protein expression in NSCLC was 47.5%.p16 protein expression was correlated with lymphnode matastasis.Conclusions p16 protein negative expression is significantly related to the lymphnode metastasis of NSCLC.It may play an important role in predicting the biological behavior and prognosis of NSCLC.