单药持续静脉输注异长春花碱治疗高龄晚期非小细胞肺癌的临床观察

Continuous Infusion of the Single-agent Vinorelbine in the Treatment of Elderly Patients with Advanced Non-small-cell Lung Cancer

目的 观察异长春花碱 (盖诺 )持续静脉输注治疗高龄晚期非小细胞肺癌 (NSCLC)的疗效和毒性。方法 盖诺 10mg静脉滴注d1 和 10mg持续静脉输注 2 4小时d1～ 5,2 8天为 1个周期 ,至少治疗 2个周期。结果 全组 3 1例 ,CR 1例 ,PR 8例 ,NC 12例 ,PD 10例 ,总有效率 2 9%。毒性反应主要为白细胞减少 ,Ⅲ +Ⅳ度 19 3 5 % (6 3 1)。结论 该方案治疗高龄晚期NSCLC具有较高的疗效 ,毒性反应轻 。

Objective To observe the response rate and toxic reaction of continuous Vinorelbine infusion in treatment of elderly NSCLC.Methods A total of 31 cases was included in the study.Vinorelbine 10mg iv drip d 1 and 10mg continuous infusion for 24 hours d 1～5 .The second treatment cycle was given after 28 days,at least 2 cycles were given.Results In 31 NSCLC patients,there were 1 CR,8 PR,12 NC,10 PD.The overall response rate was 29%.The major toxic reactions were leukopenia.Grade 3～4 leukopenia was 19.35%(6/31).Conclusions The regimen of continouus Vinorelbine infusion is more effective in the single-agent therapy of elderly NSCLC.The toxic reaction are tolerable.