DF方案化疗和放疗综合治疗局部晚期食管癌

Radiotherapy Combined with Chemotherapy with DF regimen for Local Advanced Esophageal Cancer

目的 评价DF方案化疗和放疗综合治疗局部晚期食管癌的疗效。方法 DF方案 (DDP + 5 -Fu)化疗和放疗综合治疗 98例 ,单纯放射治疗 92例。结果 化放组和单放组 1、2、3年生存率分别为 60 2 %、43 9%、3 1 6%和 44 6%、2 9 3 %、16 3 % ,3年局控率分别为 45 9%和 3 1 5 % ,3年远处转移率分别为 11 2 %和 2 2 8% ,化放组明显优于单放组 (P <0 0 5 )。化放组无严重的毒副反应。结论 DF方案化疗和放疗综合治疗能提高局部晚期食管癌的局控率 ,减少远处转移和提高生存率 。

Objective To evaluate the effect of radiotherapy combined with chemotherapy with DF regimen for local advanced esophageal cancer.Methods From January 1994 to December 1998, 190 cases of local advanced esophageal cancer were divided into two groups:1.98 patients treated with radiotherapy combined with chemotherapy with DF regimen(R+C group);2.92 patients treated with radiotherapy alone (R group).Results The 1-,2-,3-year survival rates were 60.2%,43,9%,31.6% in R+C group and 44.6%,29.3%,16 3% in R group,respectively.The survival rates in R+C group were much better than those in R group ( P <0.05).The 3-year local control rates were 45 9% in R+C group and 31 5% in R group ( P <0 05).The 3-year distant metastasis rates were 11.2% in R+C group and 22.8% in R group ( P <0.05).There was no serious toxicity in R+C group.Conclusions Radiotherapy combined with chemotherapy with DF regimen for local advance esophageal cancer can notably improve local control rate,dicrease distant metastasis and improve survival rate of esophageal cancer without increasing serious toxic therapyreastions or complications.