影响卡波姆-羟丙基甲基纤维素粘附片粘附性质的因素考察

Evaluation of factors on the adhesive properties of carbopol-HPMC adhesive tablets

目的:研究影响卡波姆(Carbopol)-羟丙基甲基纤维素(HPMC)粘附片粘附性质的各种因素。方法:测定Carbopol、HPMC及其不同比例混合物制备粘附片的粘附力、溶胀速率和粘附时间。结果:Carbopol与HPMC以一定比例混合后制成粘附片的粘附力和溶胀速率随HPMC含量增加而下降,而粘附时间与二者比例有关。结论:当Carbopol与HPMC的比例为1:1或1:2时,制备的粘附片具有较大的粘附力、适宜的溶胀速率和较长的粘附时间。

OBJECTIVE The adhesive characteristics and factors affecting properties of the adhesive tablets were studied. METHODS The adhesive tablets with different composition of Carbopol and HPMC were prepared and the adhesive characteristics such as adhesive force, swelling rate and adhesive times were determined. RESULTS The results showed that the adhesive force and swelling rate of Carbopol-HPMC adhesive tablets decreased while the amount of HPMC raised,and the adhesive times were related to the ratio between Carbopol and HPMC. CONCLUSIONS The adhesive tablets have suitable adhesive force, swelling rale and adhesive time when the ratio of Carbopol to HPMC is 1 :1 or 1 :2.