摘要
Prostaglandin J2 (PG J2) and its metabolites are naturally occurring derivatives of Prostaglandin D2 (PG D2). The pathway for formation of these compounds involves sequential conversion of PG D2 to PG J2, and 15-deoxy-△12,14-prostaglandin-J2 (15d-PGJ2). 15d-PGJ2 is a high-affinity ligand for peroxisome proliferation-activated receptor gamma (PPAR7), it represses several genes in different cell lines. Our previous studies have demonstrated that 15d-PGJ2 induced apoptosis in ECV304 endothelial cells. However, the mechanism remains unclear. In this paper, our aim was to explore the molecular mechanism of 15d-PGJ2 on apoptosis in ECV304 endothelial cells. Hoechst 33258 staining, terminal deoxynucleotidyl transferase-
