摘要
During apoptosis cells undergo a series of evolutionary conserved biochemical and morphological changes that include the loss of cell volume or an apoptotic volume decrease (AVD). This AVD response distinguishes apoptosis from other forms of cell death such as necrosis. Experiments in our laboratory and others have shown that AVD is both an early and necessary component of apoptotic death. We have now investigated the molecular basis for the AVD response in Jurkat cells and Hepatoma cells induced to undergo apoptosis with a variety of death stimuli. Our data reveal significant alterations in the flux of both sodium
