摘要
SR proteins are essential splicing factors required for constitutive splicing and serving as key regulators of alternative RNA splicing. SR proteins purified from late vaccinia virus infected cells (SR-VV) are hypo-phosphorylated and functionally inactivated as splicing regulatory proteins by a virus-induced partial dephosphorylation, similar to that seen late during an adenovirus infection [Kanopka et al., Nature 393, 185-187, 1998; Huang et al., submitted). In addition, incubating SR-VV or SR-Ad under conditions which restores the phospho-epitopes to the SR proteins regains their activity as splicing represser proteins. Here, we showed that that several genes were up-regulated in at least 50% chemoresistant AML patients, of
