紫杉醇生物合成相关酶类的研究进展

Progress of the studies on enzymes in taxol biosynthesis

紫杉醇是红豆杉属植物次生代谢产物之一 ,是近 2 0年来抗癌药物研究领域的重要发现。弄清楚紫杉醇合成途径和相关酶的反应可以从根本上大大提高紫杉醇的产量。综述近几年来紫杉醇生物合成途径中相关酶的研究工作 ,包括已经得到相应cDNA克隆的紫杉二烯合成酶 ,细胞色素P4 50 氧化酶和 3个紫杉烷的乙酰转移酶 ,由于GGPP是紫杉醇合成的必需前体 ,HMGR和GGPP合成酶的相关情况也有简述。

Taxol is the product of yew tree that has been considered the important discover in twenty years:The yield of taxol could be improved greatly if the biosythesis of taxol and the characteristic of the enzymes were made clearly.The studies of enzymes in Taxol biosynthesis including taxadienesynthase cytychrome P 450 oxygenase and three acetyltransferases were summarized.The properties of Taxus geranylgeranyl dipnpsphate synthase and HMGR were also described because geranylgeranyl diphosphate was the indispensable precurse for taxol.