氧化、脂质过氧化在食管癌患者中的变化

Changes of oxidation and lipid peroxidatio in esophageal carcinoma patients

目的 探讨氧化、脂质过氧化在食管癌患者中的变化。方法 检测45例食管癌患者(患者组)和50例健康人(对照组)血浆维生素C(P -VC)、维生素E(P -VE)、β-胡萝卜素(P- β-CAR)和过氧化脂质(P -LPO)含量及红细胞超氧化物歧化酶(E -SOD)、过氧化氢酶(E -CAT)、谷胱甘肽过氧化物酶(E -GSH -PX)活性和过氧化脂质(E -LPO)含量。 结果 与对照组比较 ,P -VC、P -VE、P - β-CAR、E -SOD、E -CAT、E -GSH -PX值显著降低(p<0.001)P -LPO、E -LPO值显著增高(p<0.001)。结论 食管癌患者氧化。

Objective To find out the changes of oxidation and lipid peroxidatio in patients of esophageal carcinoma patients. Methods serum level of vitamin-C(P-VC), vitamin-E(P-VE),β-carotene(P-β-CAR), lipid peroxidatio(P-LPO) and content of superoxide dismutase(E-SOD), catalase(E-CAT), glutathione peroxidase(E-GSH-PX) and excessive oxidized lipid(E-LPO) in erythrocyte were detected in 45 cases of esophageal carcinoma and 50 health peoples. Comparison was made between the two groups. Results Compare to health people , there were remarkable decline of P-VC, P-VE, P-β-CAR, E-SOD, E-CAT, E-GSH-PX and remarkable increase of P-LPO and E-LPO in the esophageal carcinoma patients. Conclusions There are intensified oxidation and lipid peroxidatio in esophageal carcinoma patient.