血竭总黄酮对血小板聚集、血栓形成及心肌缺血的影响

Effect of total flavone in Sanguis Draconis on platelet aggregation,thrombus formation and myocardial ischemia

目的 观察血竭总黄酮对大鼠及兔血小板聚集、血栓形成及心肌缺血的影响。方法 采用体外血小板聚集、大鼠体内深静脉血栓形成及结扎冠状动脉所致急性心肌缺血实验模型。结果 血竭总黄酮对体外 ADP诱导的大鼠血小板聚集及 PAF诱导的兔血小板聚集有一定的抑制作用 ;可明显抑制大鼠实验性深静脉血栓形成及结扎冠状动脉所致急性心肌缺血面积。结论 血竭总黄酮具有一定的活血化瘀和抗血小板。

Object To investigate the effect of total flavone in Sanguis Draconis (tFSD) on platelet aggregation, thrombus formation and myocardial ischemia in rat and rabbit. Methods Adopting the experimental models including in vitro platelet aggregation in rat and rabbit, in vivo thrombus formation in rat internal vein, and acute myocardial ischemia by ligating the coronary artery. Results In vitro, tFSD could, to a certain degree, inhibit the platelet aggregation induced by ADP and PAF. Moreover, tFSD could markedly restrain artificial thrombus formation in rat internal vein and the area of acute myocardial ischemia after ligating the coronary artery. Conclusion tFSD has the function of promoting blood circulation and removing blood stasis, anti thrombosis, together with platelet aggregation inhibition.