洛索洛芬钠治疗强直性脊柱炎的疗效与安全性评价

The efficacy and safety of loxoprofen sodium in the treatment of ankylosing spondylitis

目的 :观察洛索洛芬钠 (乐松 )治疗强直性脊柱炎 (AS)的疗效与安全性。方法 :选择 5 2例活动性AS患者 ,口服洛索洛芬钠 ,6 0mg ,tid。分别在 0周和第 4周末进行疗效和安全性评价。结果 :可评价患者共 5 0例 ,2例脱落。经过 4周的治疗 ,乐松对AS患者的总有效率为 92 .4 2 % ,其中对各主要疗效指标均有明显改善 (P <0 .0 5 )。耐受性较好 ,不良反应发生率仅为 8% ,主要为轻中度的胃肠道不适 ,无严重或危及生命的不良反应发生。结论 :洛索洛芬钠通过其抗炎镇痛作用对活动性AS的疼痛与功能受限有较好的改善 ,安全性较好。

Objective:To study the efficacy and safety of loxoprofen sodium in the treatment of ankylosing spondylitis (AS) patients.Methods:52 AS patients were enrolled in a random order,open trial.Each patient received loxoprofen sodium at a dosage of 60mg,tid,taking after meals.The efficacy and safety assessment were performed at 0 and 4 weeks after taking the medicine.Results:All data were available in 50 patients who completed the trial with 2 drop outs.After 4 weeks of treatment, 92.42% of the AS patients responded to loxoprofen sodium.Significant improvements were noticed in all 3 primary outcome measurements( P <0.05).Loxoprofen sodium were well tolerated in most patients.Only 8% of the patients had side effects, maily discomfort in stomach.There were no serious or life threatening side effects. Conclusion:Loxoprofen sodium is a reasonably strong non steroidal anti inflammatory drug for AS patients with good safety profile.