摘要
目的 研究川芎嗪对小鼠银屑病模型的影响。方法 采用腹腔注射已烯雌酚制备小鼠银屑病实验模型[1] ,从腹腔分别注射不同剂量 (5mg/kg~ 15mg/kg)的川芎嗪 ,观察小鼠阴道上皮细胞及尾部鳞片的变化。结果 川芎嗪各剂量组使小鼠阴道上皮细胞有丝分裂指数均明显降低 ;小鼠尾部鳞片的颗粒层形成数增高 ,且有剂量依赖性。结论 川芎嗪对银屑病实验模型小鼠阴道上皮细胞有丝分裂有明显抑制作用 ;对小鼠尾部鳞片中颗粒层有增加作用。
Objective This research is related to the affection on mouse psoriasis model by controlling the use of tetramethelpyrazine(TMP).Methods The researcher injects different amount of TMP(5~15 mg·mg -1 )to observe the different result of mouse on its epithelial cells of vagina in karyokinesis,and the changes on tail scale.Results The different amount of TMP experiment indicates that the use of TMP obviously decrease the mouse epithelial cells of vagina in karyokinesis,and the TMP leads to the increase of granular layer on mouse tail scale.Conclusion TMP may obviously decrease the mouse epithelial cells of vagina in karyokinesis,and may increase the granular layer of its tail scale.
出处
《医学新知》
CAS
2002年第4期189-190,共2页
New Medicine
关键词
川芎嗪
银屑病
小鼠
阴道上皮细胞
有丝分裂
尾部鳞片
颗粒层
Tetramethelpyrazine
Psoriasis
Mouse
Epithelial cells of vagina
Karyokinesis
tail scale
Granular layer