Salen-Co(III)手性催化剂的合成与外消旋环氧化合物的水解动力学拆分

Synthesis of Chiral Salen-Co(III) Complex and Catalyzed Hydrolytic Kinetic Resolution of Racemic Epoxides

将 (S ,S) 1,2 二苯基乙二胺 (DPEDA)与 2 羟基 5 甲基 3 叔丁基苯甲醛缩合 ,得到手性Salen ,再与Co络合 ,氧化后得到Salen Co(III)手性催化剂 ,用于催化外消旋环氧化合物的水解动力学拆分 ,得到了光学活性的环氧化合物和二醇 ,产率较高 ,对映体过量 2 0 .6 %～ 6 1.6 % .

Condensation of (S,S)-DPEDA with 3-tert-butyl-2-hydroxy-5-methylbenzaldehyde gave the chiral salen. Chiral Salen reacted with cobalt acetate and oxidized to give the Salen-Co(III) complex (S,S)-2, which catalyzes the hydrolytic kinetic resolution of racemic epoxides to afford chiral epoxides and diols in good yield with the e.e. ranging from 20.6% to 61.6%.