三棱、莪术抗大鼠免疫性肝纤维化研究

Experimental Study on Rhizoma Sparganii and Radices Zedoariae Treating Hepatic Fibrosis

目的:研究三棱、莪术抗肝纤维化的作用。方法:以腹腔注射猪血清制备大鼠肝纤维化模型,以ALT,GGT,TP,Alb,A/G比值,ⅣC,LN,HA及肝脏组织病理变化为指标,观察三棱、莪术对大鼠免疫性肝纤维化的影响。结果:三棱、莪术能提高肝纤维化大鼠TP,Alb含量及A/G比值,降低ALT,GGT,ⅣC,LN,HA的作用,并能改善肝脏组织病理学变化。结论:三棱、莪术有保护肝细胞、减轻肝细胞变性坏死,恢复肝细胞结构和功能;减少纤维组织增生、阻止纤维化发展,促进纤维组织降解的作用。

Objective: To study the effects of rhizoma sparganii and radices zedoariae on hepatic fibrosis. Method: The rat im-munohepatic fibrosis model was made by intraperitoneal injection of porcine serum and treated with rhizoma sparganii and radices zedoariae. The ALT,GGT,TP, ALb, A/G, IVC,LN,HA and the pathological change of the liver were observed. Result: Rhizoma sparganii and radices zedoariae could increase TP, ALb, A/G, decrease ALT, GGT, IVC, LN, HA and improve the pathological change. Conclusion: Rhizoma sparganii and radices zedoariae can protect hepatic cells, alleviate degeneration and necrosis, recover structure and function, and reduce the proliferation of fibrous tissue.