Reiter综合征——附2例报告及文献复习

Reiters syndrome: report of 2 cases and review of literature

目的 探讨Reiter综合征的病因、临床特点、治疗方法。方法 报告2例并检索收集国内文献171例,共计173例Reiter综合征,对其临床资料进行分析讨论。结果 173例Reiter综合征的男女之比为5.4∶1,平均发病年龄为27±10岁。完全型126例,不完全型67例。继发于感染106例,HLA-B27阳性59/72例。控制感染后经消炎痛、泼尼松、甲氨蝶呤等治疗后,均能达到临床完全缓解。结论Reiter综合征是病原体感染诱发的自身免疫性疾病,预后良好。

ObjectiveTo investigate the pathogenesis、clinical manifestation and effective therapy of Reiters syndrome. MethodsTwo cases of Reiters syndrome were reported. We reviewed Chinese literature and collected 171 cases of Reiterssyndrome. Clinical data of 173 patients with Reiters syndrome were analyzed.ResultsIn 173 cases of Reiters syndrome, theratio of male to female was 5.4∶1. The mean age of onset was 27±10 years old. There were 106 cases of whole-type and 67 casesof non-whole-type. 106 cases proceeded from infectious diseases. HLA-BA27 was positive in 59/72 patients. All patients were curedby indomethacinum, predoisone and methotrexatum after controlling the infection.ConclusionsReiters syndrome is a kind ofinfectious autoimmunity disease which has a good prognosis.