糖尿病周围神经病变危险因素分析

Analysis on risk factors of diabetic peripheral neuropathy in diabetic patients

[目的]探讨糖尿病周围神经病变(DPN)的危险因素。[方法]对714例糖尿病患者作肌电电生理检查,分为糖尿病周围神经病变组与非周围神经病变组,测定了体重指数、血压、血糖、HbAlc、果糖胺、胰岛素、C肽、血脂、尿白蛋白排泄率(UAER)等。对多个危险因素作单因素及Logistic回归模型多因素分析。[结果]单因素分析显示DPN组之年龄、病程、收缩压、空腹及餐后2h血糖、HbAlc、TCho、LDL-C、Lp(a)、UAER水平显著高于非DPN组,餐后2h血C肽水平显著低于非DPN组。多因素分析结果表明年龄、病程、空腹血糖、UAER、TG与DPN呈显著正相关,餐后2h血C肽与DPN呈显著负相关。[结论]年龄、病程、空腹血糖、餐后2h血C肽、UAER、甘油三酯是DPN的危险因素。

[Objective] To study the risk factors in the patients with diabetic peripheral neuropathy. [Methods] 714 type 1 or type 2 diabetic patients were tested for the nerve conduction velocities (NCV). The patients were divided into diabetic peripheral neuropathy group and non-diabetic peripheral neuropathy group. Body mass index (BMI), blood pressure, blood glucose, HbAlc, plasma fructosamine (FTS), insulin, C peptide, lipid and urirary albumin excretion rate (UAER) were measured for all the patients. All the risk factors were included in the statistical analysis. [Results] Age, duration of diabetes, systolic blood pressure, fasting plasma glucose, 2-hour postprandial plasma glucose, HbAlc, TCho, LDL-C, Lp( a) and UAER in diabetic peripheral neuropathy group were significantly higher than that in non - diabetic peripheral neuropathy. The level of 2 - hour postprandial plasma C peptide was significantly lower than that in non - diabetic neuropathy group. [Conclusion] By logistic regression analysis, it was found that the significant risk factors of diabetic peripheral neuropathy in diabetic patients were age, duration of diabetes, fasting plasma glucose, 2 - hour postprandial plasma C peptide, UAER and TG.